Eplerenone Post Acute Myocardial Infarction Heart Failure Efficacy and Survival Study
Initiatives
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Aldosterone blockade reduces mortality and morbidity among patients with severe heart failure. We conducted a double-blind, placebo-controlled study evaluating the effect of eplerenone, a selective aldosterone blocker, on morbidity and mortality among patients with acute myocardial infarction complicated by left ventricular dysfunction and heart failure.
*Note: All published information has been collected from the article referenced in the Marker Paper box below. Therefore, there may be variations with more advanced versions of the study.*
| Investigators | Contacts |
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Design
- Study design
- Clinical trial cohort
- Follow Up
- mean follow-up of 16 months
Marker Paper
Pitt B, Remme W, Zannad F, Neaton J, Martinez F, Roniker B, Bittman R, Hurley S, Kleiman J, Gatlin M; Eplerenone Post-Acute Myocardial Infarction Heart Failure Efficacy and Survival Study Investigators. Eplerenone, a selective aldosterone blocker, in patients with left ventricular dysfunction after myocardial infarction. N Engl J Med. 2003 Apr 3;348(14):1309-21. doi: 10.1056/NEJMoa030207. Epub 2003 Mar 31. Erratum in: N Engl J Med. 2003 May 29;348(22):2271.
PUBMED 12668699
Recruitment
- Sources of Recruitment
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- Individuals
Number of participants
- Number of participants
- 6,632
- Number of participants with biosamples
Access
Availability of data and biosamples
| Data | |
| Biosamples | |
| Other |